ProSpec-4-1BBR Human, Sf9

4-1BBR Human, Sf9

Catalogue number

CYT-931

Synonyms

Tumor Necrosis Factor Receptor Superfamily, Member 9, T-Cell Antigen 4-1BB Homolog, 4-1BB Ligand Receptor, T-Cell Antigen ILA, CD137 Antigen, CDw137, CD137, ILA, Interleukin-Activated Receptor, Homolog Of Mouse Ly63, Induced By Lymphocyte Activation , Homolog Of Mouse 4-1BB, Receptor Protein 4-1BB, T Cell Antigen ILA, 4-1BB, Tumor necrosis factor receptor superfamily member 9.

肿瘤坏死因子受体超家族，成员 9，T 细胞抗原 4-1BB 同源物，4-1BB 配体受体，T 细胞抗原 ILA，CD137 抗原，CDw137，CD137，ILA，白介素激活受体，小鼠 Ly63 同源物，诱导通过淋巴细胞激活，小鼠 4-1BB 同源物，受体蛋白 4-1BB，T 细胞抗原 ILA，4-1BB，肿瘤坏死因子受体超家族成员 9。

Introduction

4-1BBR is a member of the TNF-receptor superfamily.

4-1BB receptor contributes to the clonal expansion, survival, and development of T cells.4-1BBRcan also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

4-1BB 受体有助于 T 细胞的克隆扩增、存活和发育。4-1BBR 还可诱导外周单核细胞增殖，增强 TCR/CD3 触发激活诱导的 T 细胞凋亡，并调节 CD28 共刺激促进 Th1 细胞回应。这种受体的表达是由淋巴细胞激活诱导的。已显示 TRAF 衔接蛋白与该受体结合并转导导致 NF-kappaB 激活的信号。

Description

4-1BBR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids and having a molecular mass of 45.3kDa.

在 Sf9 杆状病毒细胞中产生的 4-1BBR 是单条糖基化多肽链，含有 411 个氨基酸，分子量为 45.3kDa。

4-1BBR is expressed with a 242 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

4-1BBR protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90.0% as determined by -PAGE

Amino acid sequence

ADLFERTRSL QDPCSNCPAG TFCDNNRNQI CSPCPPNSFS SAGGQRTCDI CRQCKGVFRT RKECSSTSNA ECDCTPGFHC LGAGCSMCEQ DCKQGQELTK KGCKDCCFGT FNDQKRGICR PWTNCSLDGK SVLVNGTKER DVVCGPSPAD LSPGASSVTP PAPAREPGHS PQLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。