ProSpec-ANGPTL2 Human/CYT-765

Angiopoietin-related protein 2, Angiopoietin-like protein 2, ANGPTL2, ARP2, HARP.

血管生成素相关蛋白 2、血管生成素样蛋白 2、ANGPTL2、ARP2、HARP。

Angiopoietins belong to the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietins-1, 2 and 4 partake in the formation of blood vessels. ANGPTL2 displays angiogenic effects. Angiopoietin-like Protein 2 is an anti-diabetic factor. ANGPTL2 induces sprouting in endothelial cells through an autocrine and paracrine action. ANGPTL2 increases insulin sensitivity in adipocytes. In addition, ANGPTL2 is a mediator of chronic adipose tissue inflammation. ANGPTL2 is widely expressed in the heart, small intestine, spleen and stomach. ANGPTL2 is also found in lower levels in the colon, ovary, adrenal gland, skeletal muscle and in prostate.

血管生成素属于血管内皮生长因子家族，是唯一已知的主要对血管内皮特异的生长因子。 血管生成素-1、2 和 4 参与血管的形成。 ANGPTL2 显示血管生成作用。 血管生成素样蛋白 2 是一种抗糖尿病因子。 ANGPTL2 通过自分泌和旁分泌作用诱导内皮细胞发芽。 ANGPTL2 增加脂肪细胞的胰岛素敏感性。 此外，ANGPTL2 是慢性脂肪组织炎症的介质。 ANGPTL2在心脏、小肠、脾和胃中广泛表达。 ANGPTL2 也存在于结肠、卵巢、肾上腺、骨骼肌和前列腺中的较低水平。

ANGPTL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 481 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 56kDa .

在大肠杆菌中产生的 ANGPTL2 Human Recombinant 是一个单一的、非糖基化的多肽链，包含 481 个氨基酸，包括一个 10 个氨基酸的 N 端 His 标签。 总分子量为56kDa。

Escherichia Coli.

Filtered White lyophilized powder.

ANGPTL2 was filtered and lyophilized from 0.5mg/ml in 0.03M Acetate buffer pH 4.0.

It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, an intensive dilution by relevant buffer to a concentration of 10?g/ml is recommended. In higher concentrations the solubility of the ANGPTL2 is limited. ANGPTL2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

建议加入 0.1M 醋酸盐缓冲液 pH-4 制备约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 为了转化为更高的 pH 值，建议使用相关缓冲液将其充分稀释至 10?g/ml 的浓度。 在较高浓度下，ANGPTL2 的溶解度是有限的。 ANGPTL2 不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Greater than 95.0% as determined by -PAGE.

MKHHHHHHASQEDGFEGTEE GSPREFIYLN RYKRAGESQD KCTYTFIVPQ QRVTGAICVN SKEPEVLLEN RVHKQELELL NNELLKQKRQ IETLQQLVEV DGGIVSEVKL LRKESRNMNS RVTQLYMQLL HEIIRKRDNA LELSQLENRI LNQTADMLQL ASKYKDLEHK YQHLATLAHN QSEIIAQLEE HCQRVPSARP VPQPPPAAPP RVYQPPTYNR IINQISTNEI QSDQNLKVLP PPLPTMPTLT SLPSSTDKPS GPWRDCLQAL EDGHDTSSIY LVKPENTNRL MQVWCDQRHD PGGWTVIQRR LDGSVNFFRN WETYKQGFGN IDGEYWLGLE NIYWLTNQGN YKLLVTMEDW SGRKVFAEYA SFRLEPESEY YKLRLGRYHG NAGDSFTWHN GKQFTTLDRD HDVYTGNCAH YQKGGWWYNA CAHSNLNGVW YRGGHYRSRY QDGVYWAEFR GGSYSLKKVV MMIRPNPNTF H.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。