ProSpec-ANGPTL3 (243-460) Human/CYT-902

ANGPTL3 Human

Angiopoietin-like Protein 3 Human Recombinant
CYT-902
ProSpec-ANGPTL3 (243-460) Human/CYT-902 5µg
ProSpec-ANGPTL3 (243-460) Human/CYT-902 20µg
ProSpec-ANGPTL3 (243-460) Human/CYT-902 1mg

Catalogue number

CYT-902

Synonyms

Angiopoietin-Like 3, ANGPT5, Angiopoietin 5, FHBL2, ANG-5, Angiopoietin-Related Protein 3, Angiopoietin-Like Protein 3, Angiopoietin-5, ANL3, Angiopoietin-related protein 3.

Introduction

ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins . Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain and not the C-terminal fibrinogen-like domain increased the plasma triglyceride levels in mice.

ANGPTL3和ANGPTL4是主要由肝脏分泌和表达的血管生成素样蛋白，它们的作用是通过抑制富含甘油三酯的脂蛋白的脂解来调节甘油三酯代谢。如实验数据所示，在不同的营养状态期间，循环甘油三酯的水平由 Angptl3 和 Angptl4 通过对脂蛋白脂肪酶的差异抑制来调节。 ANGPTL3 的分子结构与血管生成素相似。使用人血管生成素 5 的缺失突变体来证明 N 端结构域而不是 C 端纤维蛋白原样结构域增加了小鼠血浆甘油三酯水平。

Description

ANGPTL3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 239 amino acids and having a molecular mass of 27.7kDa.

ANGPTL3 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ANGPTL3 Human Recombinant 在大肠杆菌中产生，是一个单一的、非糖基化的多肽链，含有 239 个氨基酸，分子量为 27.7kDa。

ANGPTL3 在 N 端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

ANGPTL3 protein solution containing 20mM Tris-HCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MPAECTTIYN RGEHTSGMYA IRPSNSQVFH VYCDVISGSP WTLIQHRIDG SQNFNETWEN YKYGFGRLDG EFWLGLEKIY SIVKQSNYVL RIELEDWKDN KHYIEYSFYL GNHETNYTLH LVAITGNVPN AIPENKDLVF STWDHKAKGH FNCPEGYSGG WWWHDECGEN NLNGKYNKPR AKSKPERRRG LSWKSQNGRL YSIKSTKMLI HPTDSESFE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.