ProSpec-APO D Human, GST/CYT-652

Apolipoprotein D, Apo-D, ApoD.

Apolipoprotein-D is mainly associated with high density lipoproteins in human plasma. Apolipoprotein-D is an atypical apolipoprotein and, based on its primary structure, Apolipoprotein-D is a member of the lipocalin family. Lipocalins adopt a beta-barrel tertiary structure and transport small hydrophobic ligands. Apolipoprotein-D binds cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid.
Apolipoprotein-D is expressed in numerous tissues having high levels of expression in spleen, testes and brain. Apolipoprotein-D is present at high concentrations in the cyst fluid of women with gross cystic disease of the breast, a condition associated with increased risk of breast cancer. Apolipoprotein-D accumulates in regenerating peripheral nerves and in the cerebrospinal fluid of patients with neurodegenerative conditions, such as Alzheimer’s disease. Apolipoprotein-D participates in maintenance and repair within the central and peripheral nervous systems. Apolipoprotein-D is a multi-ligand, multi-functional transporter and transports a ligand from 1 cell to another within an organ, scavenge a ligand within an organ for transport to the blood or could transport a ligand from the circulation to specific cells within a tissue.

载脂蛋白-D主要与人血浆中的高密度脂蛋白有关。载脂蛋白-D 是一种非典型载脂蛋白，根据其一级结构，载脂蛋白-D 是载脂蛋白家族的成员。脂质运载蛋白采用β-桶三级结构并运输小的疏水配体。载脂蛋白-D 结合胆固醇、孕酮、孕烯醇酮、胆红素和花生四烯酸。
载脂蛋白-D在脾脏、睾丸和脑中具有高水平表达的许多组织中表达。载脂蛋白-D 以高浓度存在于患有严重乳腺囊性疾病的女性的囊液中，这种疾病与乳腺癌风险增加有关。载脂蛋白-D 积聚在再生的周围神经和患有神经退行性疾病（如阿尔茨海默病）患者的脑脊液中。载脂蛋白-D 参与中枢和外周神经系统的维护和修复。载脂蛋白-D 是一种多配体、多功能转运蛋白，可将配体从一个细胞转运到器官内的另一个细胞，清除器官内的配体以转运到血液中，或者可以将配体从循环转运到器官内的特定细胞组织。

APO-D Human Recombinant full length protein expressed in E.coli, shows a 48 kDa band on -PAGE.
The APO-D is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered clear solution.

APO-D protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。